I'm not sure I understand what Zephyr has to do with running Python scripts.
If all I needed was an RTOS kernel then I'd have to look no further than FreeRTOS. The problem is that most projects I do these days require much more than that, e.g. networking, USB support, bluetooth, SD-Card file system, etc. Sure, you can cobble something together from various open source projects, but that's far from ideal. There used to be eCos which was pretty good but it seems to have passed into obscurity with nothing much to replace it. I was hoping Zephyr might finally fill this gap. These days I often find myself "upscaling" a design to use a Linux based system on module simply to get reliable networking, USB, bluetooth etc etc... Obviously that is not possible for many designs where cost or space is an issue.