Lately Msoft as issued printer drivers updates and messed up a few things
Normally you should block any drivers updates in Win10, it will help stabilise windows and attached peripherals, there is some nirsoft utilities to clean and or remove unused com ports if i recall
Windows suck real bad in the device manager, it will show active com port even when the devices are removed ....
Some softwares hate com prots higher than com4, in the device manager on the com port(s) check if they are set at 115200 bauds, its 9600 by default and some software may hang if the baud spped doesn't match ...
You could use hibit uninstaller portable, it could help get rid of the software and registry entries ??
You can intercept the driver installation before clicking install by checking in the user local temp folder the extracted driver(s) package ??