Where would you route the trace?
If it's going around the outside of Cin or Cout, you get extra stray inductance. Which for something that's gotta be in the 10ns switching speed range, is a good way to introduce more noise to the regulator and surrounding circuit.
If you moved Cin where R1/R2 are, and connected them with a bottom side trace and vias instead (which is perfectly fine, the feedback path is low current, it doesn't need good layout), you can get a good low-impedance path for Vin. You could swap Cout around as well, so now Vin, GND and Vout are on the top side.
The comment about where ground plane connects is kind of poorly phrased, but you want to connect where the three caps Cin1 and Cout2 (why is it Cin and Cin1, but Cout and Cout2? Go figure..) are. Noise currents from each cap are returned at this point, and a point is small so it doesn't have voltage drop across it, which means you avoid common mode noise this way. This assumes no AC currents flow through Vin or Vout of course, which can be enforced by placing chokes here (small ones, under 1uH will be fine).
Again, to enforce the current balance at the common point, you don't actually want ground connected around the rest of this circuit. So you could make a U-shaped slot in the ground pour to enforce this. There may be some voltage across this slot (some fraction of the ground loop voltage within its perimeter), but it is relatively short, and so, unlikely to be a source of radiation; and also relatively easily damped or shielded at such frequencies (inches-long slot <--> ~low GHz).
Tim