Ok it's not as bad as I thought, since I see you aren't some kind of troll or worse audiophool DIY "i can do it better" kind of nut

there are still a couple of issues
- the technology, as you probably are aware, sub-micron design is much more challenging than above, since the classical model for the MOS transistor doesn't hold any more (well it really start to fall apart at 1 um already) and since we are in highly scaled devices kind of world and here lies the problem with the tools you want to use, the problem is that between classic MOS model and real device there start to be 20-30% difference, and this depends quite badly on the process used, so to cut a long story short you will need to use a PDK, and the problem with Electric is that no one uses it (for real ic manufacturing at least), so foundries will not put effort into building a dev-kit, nor into testing a ported one.
-the second issue is that you to be aiming at a mixed signal IC, with a DSP, DAC and analog, and this is a pretty big system, the worst part is that having digital on die, is creating you much much more problems than it solves, think at mixed signal pcb design problems, well the one's you'll be facing will be pretty much the same, just on steroids, since with smaller distances you'll get much greater coupling between nodes of the circuit, and here is where post layout sim will be handy, you might have some coupling between a clock line/digital singnal and an analog node, and you wont see it until you get your IC fabbed, and it get's worse, it might be that the problem is only in certain units, or worse in all the units but in some specific operating condition (Vdd, Temperature, load etc) that might be impossible to catch even with thorough testing
as for QA I wasn't thinking about csutom test jigs, but a more basic testing that every reputable manifacturer will do on every wafer, in the gaps between 2 dies they will place some test dispositives (resistors, capacitors MOS and so on) they will then test them, and if the value of the key parameters(resisance/square, capacitance and so on) is outside of the range between plus sigma and minus sigma from the mean value, then the wafer will be rejected, and you wont see it, if you decided to go to a crappy chineese low cost fab, to get better price they may skip this test and send you wafers with ultra bad performances
So if you are still interested in doing this, the first thing is to use a commercial EDA package (be it tanner or cadence), I'm afraid you cannot escape it, if you want to use advanced tech ( 0.35 is still pretty advanced for a low frequency analog design)..
let's talk about the technology now, you will probably need 2 or 3 options as basic (digital version) cmos process probably wont be enough, the first and foremost is the High Resistivity Poly resistors, and PIP (poly-insulator-poly) or MIM (metal-insulator-metal) capacitors this two options will give you linear resistors and capacitors suitableto analog circuits, you'll probably need also thick oxide transistors if you want 5V compatibility, since core devices go only up to 3.3V (at least in the 0.35 AMS process i used, but I think it's a pretty common thing)
now with your process sorted, we can think about the actual design of the thing, the best would be to split the digital part and put it in an FPGA (or board type of solution with discrete dac and stuff, depends on what you need to do), and do an analog only IC, that will give you much less problems, I would stay away from switched caps as long as you can, and use Ratiometric circuits instead (the ones that does depend only on the ratios of two values) since you'll have very very small mismatch between devices on the same diem, think it this way, Op-amp inverting amplifier, is safe because [R1=10K, R2=1K] or [R1=12K R2=1.2K] is the same, what is not safe are thing like passive filters since they depend on the absolute value of a component, another technique might be to put critical passives on the board, instead of integrating them, since 0.1% SMD resistors/caps are quite cheap, the choice is not without disadvantages though (more pins are needed and different temperature coefficients).
The filter cannot be integrated, not a passive one at least, you could opt for an active one instead though, for the dac I would suggest using a switched courrent source one, since courrent mirrors are extreamely cheap and easy to make( you'll want to use a wide swing cascode mirror), swithced caps circuits are not