LoRa has one of the highest link budgets of any readily available consumer kit, it that doesn't work I'd be very surprised and you're pretty much out of luck. As I think others have already mentioned, the signal doesn't need to travel line-of-sight through the building, assuming there are other buildings and objects around there will be plenty of room for multipath propagation.
If for some reason it doesn't work, the first thing I would try is replacing the fully loaded coil antenna with a full or half wavelength whip antenna or dipole rather than immediately putting in a power amplifier. If you add a PA you will almost certainly breach your local regulations on RF power emissions and the module you have probably already outputs more than enough power (100mW or so should be plenty).