Anyway, since this the OP intends to use a LiPo, low Iq doesn't matter. The self discharge will probably be in the hundreds of μA,
A nice example of the classical false assumption which leads to all those nasty crap devices which self-destruct.
Okay, take a small li-ion pouch cell, say around 1Ah. The self-discharge of an empty cell is not "hundreds of uA", not even "tens" - if it was, the cell would self-destruct by self-discharging itself beyond low-voltage cutoff, finally causing low-voltage damage (copper dissolution). But this does not happen. I have tried to measure the self discharge of empty(ish) cells, and it just is impossible to measure given standard external means. During my 1.5 years of test time, none of the dozen samples lost any measurable charge below about 50% SoC, not even at elevated temperatures.
Now, if you indeed assume that the cell self-discharges at "hundreds of uA" anyway, and so it is OK to add external load in a similar range, you end up with this classical broken-by-design gadget:
1) The user buys your battery-powered product (can be a $1 toy, a $10000 special instrument, or a $100000 EV car, the principles are the same)
2) They charge it, turn it on, play with it
3) The battery goes empty, the user turns it off,
4) The user has something else to do
5) The user comes back to the product after a month or two - with worst offenders, just after a
week - it's a brick.
6) If(expensive && userbase_has_clue) warranty_repair_nightmare_ensues(); else user_throws_it_into_bin();
This is surprisingly commonplace in both cheap Chinese throw-away toys, and expensive "professional" products. This is actually a very common problem even in
high-end battery management systems, I have seen many which have destroyed good packs instead of protecting them, which was their only job!
Yet it's trivially easy to calculate how to avoid this problem.
Look how much charge your cell has left at the cutoff of your choice, and divide it by the worst case "off current". You need to decide one parameter, which will be "time from turn-off to self-destruction", which, unfortunately, cannot be infinite. If you don't
calculate it but do it based on hand-waving or just ignore the issue altogether, it may accidentally become just a week or two. Yet you'd like to have something around a year or so.
Regulators / MCU sleep modes with Ioff/Isleep < 10uA, even <5uA are
very much needed in the li-ion battery powered low power device market.