| Electronics > Projects, Designs, and Technical Stuff |
| COVID-19 related Engineering Data - FTLOG Data-Only Please! |
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| pipe2null:
The intention of this thread is to post harder to find COVID-19 related data that might be useful from an engineering perspective. This is a "Put data where your mouth is" kinda thing. ;) Please do not post project-specific discussion here, there is enough Jerry-Springer-Grade controversy in a multitude of other threads already. I hope this topic might be respected as a Safe haven where tangible data reigns supreme. So, please put data where your mouth is or troll elsewhere. Seriously, no offense intended. Please include a short excerpt and/or context when appropriate. My contribution, for example: Some medical professionals have used SARS-CoV as a model for COVID-19 since formal studies of the new virus were unavailable and AFAIK remain unavailable. Attached is a professional study I found on ways to effectively kill the SARS virus that includes numbers and graphs that engineers might find useful. If you have more up-to-date information or find a similar study, please post! See attached PDF. Excerpt: 2.3. UV light treatment Ultraviolet light (UV) treatment was performed on 2 ml aliquots of virus (volume depth = 1 cm) in 24-well plates (Corning Inc., Corning, NY). The UV light source (Spectronics Corporation, Westbury, NY) was placed above the plate, at a distance of 3 cm from the bottom of the wells containing the virus samples. At 3 cm our UVC light source (254 nm) emitted 4016 μW/cm2 (where μW = 10−6 J/s)... 3.1. Effect of radiation on the infectivity of SARS-CoV ... Exposure of virus to UVC light resulted in partial inactivation at 1 min with increasing efficiency up to 6 min (Fig. 1A), resulting in a 400-fold decrease in infectious virus. No additional inactivation was observed from 6 to 10 min. After 15 min the virus was completely inactivated to the limit of detection of the assay, which is ≤1.0 TCID50 (log10) per ml. 2.5. Heat treatment of virus We incubated 320μl aliquots of virus in 1.5 ml polypropylene cryotubes using a heating block to achieve three different temperatures (56, 65 and 75 ◦C). 3.2. Effect of heat treatment on the infectivity of SARS-CoV... ... At 65 ◦C, most of the virus was inactivated if incubated for longer than 4 min (Fig. 2B). Again, some infectious virus could still be detected close to the limit of detection for the assay, after 20 min at 65 ◦C. While virus was incompletely inactivated at 56 and 65 ◦C even at 60 min, it was completely inactivated at 75 ◦C in 45 min (Fig. 2C). Surprisingly, at both 56 and 65 ◦C the virus was inactivated at early time points but at 60 min a small amount of virus was detected. Related project thread(s) if applicable: (Will edit post later to link related discussion/project threads) Related open questions not effectively answered in this specific study: - What is the relationship between UVC intensity and required exposure time (for other intensity levels)? - Is UVC more/less/same as effective on water/air/aerosol/surface dwelling viruses? |
| profdc9:
Consult this document in progress https://docs.google.com/document/d/193mt42jUR8PxuONUY4A6YZsyOOmy6Psg6BDme3rjai8/edit#heading=h.tcxzsexja88t In particular, Evaluation of Five Decontamination Methods for Filtering Facepiece Respirators by Viscusi et al https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781738/ and Inactivation of SARS Coronavirus by Means of Povidone-Iodine, Physical Conditions and Chemical Reagents by Kariwa et al https://www.karger.com/Article/FullText/89211 but read over the document for the many references. |
| pipe2null:
CDC and EPA recommended COVID-19 chemical disinfectants. Also includes required disinfectant contact times for each chemical. List N: Disinfectants for Use Against SARS-CoV-2 https://www.epa.gov/pesticide-registration/list-n-disinfectants-use-against-sars-cov-2 Warning: Some of those chemicals are pretty nasty, so probably a good idea to read the directions first... ;) Attached is the complete list as of March 26, 2020. |
| pipe2null:
Study on using UVC and bright light to kill viruses including SARS-CoV in blood bags/platelets/plasma. Might be useful if you are trying to use UVC to disinfect something but don't know required UVC source wattage or exposure time. Excerpt: "...In PCs, at half of the full UVC dose (0.1 J/cm2) SARS-CoV and CCHFV infectivity levels were below the [Limit Of Detection]" UVC Light dose (cumulative)Bag1 log10 TCID50/mlBag1 log10 RFBag2 log10 TCID50/mlBag2 log10 RFOriginal A05.8 +/- 0.36.0 +/- 0.20.05 J/cm22.7 +/- 0.33.13.0 +/- 0.43.00.1 J/cm2≤2.4≥3.4≤2.4≥3.4RF = log10A0 – log10An (R,reduction factor; A0, spiked total virus load before treatment; and An, total virus load after treatment) |
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