I think that I have now all in place for redesigned AFE for MIO168 module that is based on 4-ch simultaneous sampling 24-bit ADS131E04. First I have to thank @Kleinstein once again for his selfless assistance and patience as we went through a dozen iterations. The ADS131E04 is a pin compatible with the 6- and 8-channel versions which can be handy for future upgrades.
The ADC is powered with +/-2.5 V to be able to accept a bipolar signal. A place for buffered external reference in SOIC8 packaging is also allocated. The picture also shows the driver for the latching relays shown below. In the bottom right corner are analog bus extenders that I called ADIB: these will be two 10-pin connectors on which two analog inputs with sense and guard and Gnd are exposed. On the MIO168 they will be connected to the inputs of the ADC which have active clamps on them (IC28).

I called the next AFE "Hi-voltage" because it can measure up to ±150 or ±240 V, depending on the divider used (Caddlock or discrete). For better accuracy, the voltage can be measured in three ranges. This AFE also has the option to measure current in case a 4-24 mA sensor is connected to the input. The current shunt has a limiter in front made of a combination of two depletion FETs, a resistor and a PTC, and at the AFE output there is an active clamp that cuts everything over ±2.42 V.

The next AFE I called “Hi-current” because it allows measuring of current up to 10 A in three ranges. It can also be used in voltage mode when it is possible to measure voltages up to ±15 V in two ranges.
The selection of the operating mode (voltage/current) is selected with a signal relay (ISEL_1), and hi current mode with a power relay (ISEL10A). Since the entire MIO168 is floated and uses a small DC-DC converter for isolation, it is important to take care of consumption. For this reason latching relays were used instead of regular ones. Relays with two coils are used, and the MCU will take care of set and reset actions. Relays with two coils are used, and the MCU will take care of set and reset actions.

To summarize, we'll have two pairs of AFEs that can measure voltage and current simultaneously. This means we can also measure power. In combination it can be used to measure the efficiency of, e.g. a DC-DC converter (input and output are monitored simultaneously). We basically have a rudimentary DC power analyzer as well as a entry-level DMM (the real one should follow, if we can reuse a 6.5-digit DMM module that @Kleinstein is working on). I will be more then happy if I manage to get 18-bit precision.