Using the DER DE-5000 LCR meter (test freq = 100kHz) I get these results:
SCL to GND = 115pF
SCL to 18V = 115pF
SCL to (GND+18V tied) = 116pF
GND to 18V = 6.3nF
Draw a delta of capacitors. Set one to 6.3nF. Set the other two to 58pF.
Repeat for SDA, drawing another pair of 58pFs from the 6.3nF to it.
And, possibly draw an additional capacitor between SCL and SDA, the value of which will be pretty small. Ideally a transfer capacitance measurement would be made, i.e. one electrode excited with AC with respect to surrounding grounds (planes, tied), AC current measured on the other electrode.
C_{SCL-SDA} will be small, because the capacitance to planes dominates. If they're minimum spaced, it's probably on the order of 1/10th or 6pF.
Note that you need to add the sum total of all attached cards to get the bus capacitance. If those can be measured separately, then this is easily solved for.
That is a good question, that needs some consideration.
In general having two GND planes (on a 4-layer PCB) is considered better then a GND plane and a power plane. It's especially the thin prepreg layer that improves coupling compared to the thick inner core. "Power" can be routed as tracks that can handle the current with a low enough voltage drop, but do of course need local decoupling for IC's. You may want to do some research in this area.
The main thing here is that it needs less than... 0.3V maybe, of induced noise? I2C has very little noise immunity, and this is intentional by design. Logic power planes normally have some 10s of mV if that, so make excellent reference planes; the same level out of 18V though is another about 16dB lower ripple fraction, much more strict, and worth emphasizing.
Anyway, that's all I wanted to do, highlight that concern, not make a discussion out of it.
Tim