That meter says that it does 4-wire measurement, yet the photo shows only three connectors, one of which is for a shield. Are the other two special two-wire connectors with force and sense on the same plug?
The portion of the test fixtures that plug into the DE-5000 use a double sided PCB. So you've test on one side, sense on the other (true 4 wire). The round hole is for a guard/ground line (if you choose/need to use it).
The one drawback to the other end of the fixtures, is the alligator clips or tweezers terminate the sense and test signals before reaching the CUT. Given the distances are small (~1 - 1.5"), it's not going to make that much of a difference in practice generally speaking.
But if you truly want 4 wire all the way down to the component leads, then you can disassemble an alligator clip fixture (
TL-21) and add your own wire and clips (i.e. those that the halves are insulated from one another, such as a
Mueller BU-78K or similar). And ~$22, it's not horribly expensive either.
Ideally, I'd recommend just adding 4* BNC connectors instead of wires just coming out of it, or even using banana's (better than raw wire though as strain relief through the plastic fixture enclosure isn't an issue). That way you can just connect up true Kelvin clips or a pair of tweezers that stay isolated all the way down to the CUT.

It'd be a bit more difficult with the tweezers (
TL-22), but quite doable (PCB material would be one way). that would accomplish this, and inexpensively as well. The Kelvin clips can easily out-cost the fixture (there seems to be some decent ones available on eBay and Aliexpress that are much less expensive than the Mueller's linked above).
Edit:
Krypton2035 beat me to it.
