Yes, sorry if it wasn't that clear, I think my issue here is brief overvoltage spikes, such as from the power supplies dropping into regulation, ESD and the like. The LED's themselves are the WS2812B's (integrated chip in LED). What I've found so far is that usually the first LED in the string is always the first to fail. However, since each LED has to pass all the serial data for the remaining LED's, if one dies, all the others after it won't work until you remove it either.
I had one fail right in the middle of the strip the other night, it still partially worked and passed data through, but as it got warm, it started corrupting the data to the following LED's and they'd flicker like mad. Luckily said LED was flickering pretty noticeably itself, so I was able to find it pretty easily along the strip and cut it out. But so far I've had about 3 LED's fail on me, and being in waterproof silicone tube, fixing them is annoying, so I was thinking of some sort of protection that'd make them a little more lenient to brief overvoltage spikes, both on the power and data lines.