If I'm removing the chip antenna there's loads of space for a connector like that, but also room for an end-launch SMA. Is there a benefit of the u.FL over the SMA other than size and cost? I'm inclined towards SMA since this is an outdoor device that might get thrown around a bit, so ruggedness is valuable.
If you have other connectors poking out of the PCB at fixed locations, then direct SMA may make more sense.
The u.FL-to-SMA pigtail allows one to use many different enclosures, as the SMA connector can be placed anywhere within reach.
Also note that the PCB antenna can be on a separate PCB (connected via flexible u.FL-u.FL coax cable), as that's how some Mikrotik and Teltonika 4G/LTE outdoors routers do it.
I think the Mikrotik R11e modems are a typical example:
(Click to embiggen)Because the position of the miniPCIe modem varies even among Mikrotik products supporting it, the main and diversity antenna connectors (top left and top right corners, just inside from the mounting/bracket holes) are u.FL ones so a short pigtail can be used to route them to SMA connectors on any enclosure used.
In comparison, I do have seen 4G/LTE routers that incorporate the corresponding circuitry on their main board, and they do use direct 90-degree through-hole SMA connectors to the external antennas. It is more cost-effective, and probably has a fraction of a decibel less insertion losses.
I like to also do custom enclosures (right now I have a 25cm tall birch half-stump I want to make into a wall enclosure; looks like a nature art, maybe with a round display as if it was a birdhouse), so I personally do prefer the u.FL ones allowing me more leeway with custom enclosures. Most users won't care, so I'd say using direct SMA connectors is almost as good a solution.
Why almost? Because of the enclosure-internal PCB and ceramic antennae typically come with u.FL connectors, allowing you to choose between an external SMA or RP-SMA connector (via u.FL to SMA/RP-SMA pigtail), or an internal (PCB or ceramic) antenna (via u.FL to u.FL pigtail).
For an experimental prototype, I'd definitely use the u.FL connector, because of the additional options and testing different antenna solutions it allows. For a proper product, I have no idea: me hobbyist, not product designer.