This is really too broad a question with a different answer for each combination of parameters such as how big a budget (time and money) you have, how fast the transient response needs to be, whether the converter topology is prone to issues to begin with (e.g. - boost or flyback-derived converters in CCM), how wide the input voltage range is, how wide the output voltage and load current range is, how rapidly can/will load current change (dI/dt), is the converter transformer-isolated, how expensive the product is, how serious are the consequences of failure, what kind of MTBF is needed, etc.
Over the years I've gotten fairly good at anticipating when a very casual design and validation approach can be used and when I actually need to employ more rigorous testing schedules. I used to be a proud member of the "hates SPICE" crowd but LTSpice made a believer out of me and now I use it for at least the first-pass workup of every new design, if not full AC/transient analysis of the loop. Regardless of how much simulation you do, though, you still have to verify the circuit operates correctly in the real world. Again, whether that entails full-blown frequency response analysis with a tracking generator and signal injection transformer or just toggling a bank of resistor loads on and off and looking for ringing on the scope depends on the parameters mentioned above.
For example, non-isolated buck converters - especially if slope-compensated current-mode control is used - are so easy to get working and so forgiving of their loop compensation components that you would arguably look incompetent if you had to resort to real-world frequency analysis. In contrast, a transformer isolated CCM flyback is practically metastable by design, so unless you slug the hell out of the control loop it will almost certainly have combinations of line and load (especially load dI/dt) that are outright unstable.