@tooki - no micro-USB will be in a design of mine

, the Nano like board with LEE will have micro-USB like the original Nano, the "advanced" board, with SEE and 40 pins, will have USB C connector. The 3V3 variants that nobody cares, is not that they aren't significant or super widely used, nobody cares to make a new one because most of the sweet spots for that platform have been already reached.
@psi - I have selected an MCU that works at 5V as well as 3V3, I'm interested in using it at 5V, you prefer 3V3, no problem, so for the moment this issue is solved. There is no need for I/O expanders to be used on base board, they can be added externaly if needed.
Generally speaking, I'm planning two boards, one as much as possible compatible with Nano, with NUC029LEE (7x7mm LQFP44) and one, an extended version with 40pins and the EBI bus out with NUC029SEE ( 7x7mm LQFP64) and USB-C connector to make it a bit future proof. because the belly of the boards will be free from the USB-to-Serial programming chip, both boards will get a RTC battery holder (or soldered battery for really low budget), I'm open for suggestions of what to place on the rest of the belly area that will be uesfull but not increase the costs too much.
Now that the 3V3 vs. 5V topic has been

until it become a hamburger patty, maybe we can let it rest and the knowledgeable people have a look at chosen MCU, eventually suggest another one from Nuvoton, that has a similar packaging, and better performance or peripherals (multimedia excluded).
Why Nuvoton, one because is not Mainland Chinese or mainstream, two because I can get reasonably cheap and easy chips from their portfolio and three, and the most important, YOU can get reasonably cheap and easy chips. I tried to avoid either mainstream manufacturers, or the extreme obscure ones and I think that Nuvoton fits well the middle ground.
Also when suggesting better alternatives IYNSHO, kindly please remember the scope of the project, that is practically a MCU on a PCB, attempting to be cheap, but with a bit of performance, avoid astronautic, automotive grade, mainstream stuff, that is plundered by everybody and unobtainable since 2020, also lets further restrict the architecture to ARM Cortex-M compatibles capable to run at 5V.
Any useful advice or suggestion will be thanked and appreciated

, any contrarian, "muddling the water" and "poisoning the well" shite will be ridiculed and/or ignored

.
Thanks and cheers,
DC1MC