The motivation is to recreate the ADMX3652 - 6½ Digit, ±20 V DVM, then characterize. Optionally, add a 200V range. It seems the 200V support is a completely different ballpark, and creates offset problems I can not address with the 4255's built in AZ. My guess 3652 uses 4255 in the inside.
The protection is just for the bench, to avoid any random mis-wiring or static to destroy the ADA4255 inputs. So this end, the Mosfet limiter, GDT+MOV might be sufficient, no bootstrapping or Zeners, given the fairly good amount of protections already on the Mux input stage.