Richard Crowley: What do you use to cut the aluminum channel stock? How do you join the corners of your box?
Ah, hacksaw, for basic starters. Or if you have woodworking tools, any other saw (just be extra careful!).
Corners can simply be held together by the plates, or you could add angle stock to hold them, or you could partially miter the corner (into the "throat" side of the 'C', cut 90 degree triangles out of the flanges, but leave most of the web intact) and bend it that way.

4. Thanks for the tip. I was going to start out with McMaster Carr and use blind rivets and/or threaded standoffs with low profile screws on the outside of the case. Will look around for a metal supply shop. I've always wanted a spot welder.
Also, if you're any good with SolidWorks (guessing not, haha), you can make sheetmetal sections and send the files off to a shop to have them made. Typical shop is equipped with laser, waterjet or punch cutters, CNC benders and so on, so the cost is pretty good.
Needless to say, this shoots straight from "beginner" to "professional", but just FYI.

Once you get a feel for how to cut and form sheetmetal into useful shapes (basic geometry, folding, leaving tabs/flanges for rivets, leaving clearance for tools, etc.), you can also just do hand-sketched drawings, given that you'll either need to find someone who can turn said drawings into CAD (any ME with some free time should be able to do that for a modest price), or a shop that does it for you (in which case the cost will be rolled into your parts cost).
IIRC, a typical sheetmetal prototype run looks like 10-20 pcs, lead time 2 weeks, total cost in the low $100s. Not exactly hobbyist fodder, but very affordable if you're starting small production, or you're a company that doesn't have a machine shop to do it in house.
Again on the note of PCBs, they can be used for structure, too. Mikeselectricstuff has some videos on this. PCBs are cheaper, but you have less flexibility (literally). Creative solutions include soldering PCBs edgewise, or snapping them together (a lot of makers out there use laser cut plywood, snapped together by slots and tabs -- same idea!).
I know that MIG welding galvanized metal puts off dangerous fumes, is the same true for spot welding?
Yes, but only a small puff, since the HAZ (heat affected zone) is small. Doing that in a well ventilated shop is no problem*.
*Unless you have metal fume hypersensitivity, in which case you might want to avoid that, too. Zinc fume sensitivity varies by person, and by history (sensitivity tends to increase with exposure).
One catch: galv in the middle of the joint is probably not a great thing. It should boil away as it heats up, but some will end up fused into the weld bead, some will be oxidized to slag, it might make the joint brittle or weak. Anyway, that's physical speculation -- there'll be tons of articles about this, it's a normal industrial process.
Tim