It could also be an option to use an internal switch controller and cascode a high voltage MOSFET on top of the internal switch. As long as you can find a HV MOSFET with low enough Vgs_th this is a very vaible solution. Sadly, most integrated switch controllers have fixed Fsw, particularly low voltage input ones, so I don't have any part numbers to recommend off hand.
What's your target output voltage and current? A plain boost running from 2.7 V will struggle to reach beyond 50 V due to inductor parasitics, and efficiency will be miserable. If you need more voltage than that I would consider cascaded boost converters, adding a voltage multiplier if you only need very low current, or a flyback which could be done with off-the-shelf magnetics. Even doing a tapped inductor boost using a standard 1:1 coupled inductor will help