Well, First, decide if CM or DM noise is the primary issue. Then the freq band of the noise you need to reduce. EG mains 50/60 Hz, audio, RF, UHF, microwave?
CM noise: Induced by flux common to both conductors, noise current flows equally on BOTH conductors.
Use shielded TP, and balanced connectors, diff amp type RX or transformer isolation with shield.
DM (normal mode) noise: Flows as the signal current in a loop, and hard to separate from the signal current.
Use Coax or triax, cable and connectors.
One can design baluns, beads and chokes to reduce either CM, DM or both at higher freq.
Suggest to see the fine books by Ott, etc, on noise reduction.
Jon