Is C3 rated to 600V. It's not going to be happy if C3 arcs inside and shorts the HV side to the LV side.Edit: ops, na VS is high side too.
Also is D1 reverse leakage potentially causing a problem, datasheet says its 1uA reverse leakage so at least its not 1mA,
but is it perhaps unhappy with IC VCC getting 1uA from 200V during periods when the IC is drawing much less than 1uA?
Probably unlikely to be that though.
Next time you blow one up testing i would have the scope on IC VCC set to trigger at 21V. See if it triggers and what you get
Or, could try slap a 12V 19VC TVS across IC VCC to gnd, just to see if it helps.
For C15 the 100nF might be a bit small to prevent a noisy supply when its so close to 200V switching.
Try put a 4.7uF in parallel. Just for a bit more supply decoupling from the inductive shit show happening next door.
