Insufficient ground pins.
If transmitting medium speed digital signals over a ribbon cable, it is standard practice to have 1:1 interleaved signal:ground, to minimise all the standard signal integrity problems (crosstalk, impedance, ground bounce etc).
If you aren't transmitting signals over ribbon cables, then twisted pairs are mandatory, and those also need 1:1 interleaved pinouts.
Ignore signal integrity and you will get intermittent operation and/or input/output characteristics that degrade over time.
Medium-speed means edge rates 1ns-5ns, and the period is irrelevant. Virtually all modern logic is in those ranges, and many are <1ns (e.g. 74LVC1G14 is ~600ps).
Also I don't see the decoupling capacitors and ground plane; you must follow the manufacturer's recommendations.