I find the combination of wanting "the smallest possible" in combination with a DIP NE555 quite weird. Especially since all the other parts are already SMT.
True. Even if he already has a bin fill of 555 DIPs, the surface-mount parts are about 10 cents each, and the hassle of mixed through-hole and SMD assembly would certainly drive me in the all-SMD direction.
I expect that he is concerned about soldering the SO-8 package rather than the familiar DIP.
Once he tries it, he is likely to find that the SO-8 package is faster and easier to solder than through hole parts. It's only when it gets to smaller pitch that the size becomes a problem.
I suggest reducing the number of unique parts. There isn't a good reason to have both a 4.7uF and 10uF capacitors. The power supply bypass is flexible, often optional, and can be whatever value is required elsewhere. Similarly the gate resistor can be the same 470R part used elsewhere. Or use 220R or 270R 0805 resistors everywhere. Five 270R resistors in parallel will handle the current at 5V and nominally be in spec for power. That also gives you an opportunity to experiment with smaller keep-alive current. 10-20mA should be sufficient, it shouldn't take 100mA.
I wouldn't flood pour 5V anywhere close to mounting holes or the edge. At minimum there should be a ground ring around the edge. Even if your design rule requires copper clearance to the router line, assume that your hobbyist board will be gripped by a grounded hacksaw blade and bolted down with serrated flange screws.
It doesn't apply here, but as a rule put the ground connection closest to the board edge and try to keep the power supply protected by outboard pins.
Hand soldering has more constraints than reflow. SMD components should be lined up in even parallel lines. They can be tightly adjacent, but leave a big gutter at the ends for a soldering iron. Think of the angle the tip needs to make, and don't put a tall component at the end of the gutter.
On the plus side, hand soldering means that you don't need to be as careful about thermal relief gaps around pads and pins. It only takes an extra second while soldering to add extra heat to a pad that would stubbornly refuse to reflow. No thermal relief gap means that you can better use pin headers and connected wires to carry heat away.