I've used the Si7051 in a couple projects and it's a fine sensor. It has an integrated CRC block, so you can verify the digital integrity of each measurement. The small DFN package may look intimidating for hand soldering, but it's actually pretty easy to deal with.
Of course we'd need to know what your exact application is, and what kind of accuracy you are after.
One thing to consider is the way you mount the sensors on the PCB, especially if you intend on measuring ambient temperatures. Depending on what's around them and more generally what's on the PCB, they will tend to measure an higher temperature than the ambient temperature due to small local heating. Errors of 1°C are not uncommon at all even if your circuit doesn't generate much heat. One way to work around this is to add slots around each sensor to limit heat propagation. Failing to take such proper counter-measures will completely defeat the point of using a relatively high accuracy sensor.