Prolific's current drivers don't support older chips. The older chips where cloned, so they stopped supporting them. Doesn't matter if they are genuine or fake.
Some versions of FTDI drivers won't work with the fake chips.
10 years ago those where the brands I used the most. I no longer use either.
My current favorites are the CH340C and CH340E.
FTDI drivers don't just "not work", they take aggressive actions which can cause you major headaches in a product.
Some versions of the FTDI drivers "brick" devices they decide are fake, by changing the USB ID reported by the device.
Other versions silently but intentionally corrupt the data stream. And yes, it's intentional because the corrupted data stream contains “NON GENUINE DEVICE” or something like that.
They also do not provide a program or other means to validate a particular device as being genuine.
This means that your in-production product which has been ticking along just fine suddenly can have a serious failure because of a change in the parts supply chain (Which depending on who you have manufacturing your product you may or may not have been made aware of). This failure will affect 100% of the production run, with no acceptable workaround except recalling the product and changing out the serial chips.
For this reason, nobody I work with is using FTDI devices any more.
CP2102's have been for the most part OK, but there seems to be issues with their drivers, which I think relate to excessive delays in USB driver chaining ... For example, I'm currently working on a product which uses an STM32 series device as it's main processor and has a CP2102 for the maintenance port ... guess what, the ST-LINK (primary STM32 debug interface) is unreliable or doesn't work at all on many systems while the CP2102 is connected - works perfectly when the CP2102 is not around.
Agree on the CH340s ... these are my current favorites as well.
Dave