Designed a circuit that worked beautifully in LTSpice, but oscillated like crazy when built on the actual boards. Blew 30€ on that.
So don't believe everything the computer tells you. 
In fairness to LT, if we are talking about using LTSpice to simulate their DC-DC converters, I've used it to simulate several power-supply designs based on their parts, and the designs worked correctly on the bench. Of course, you really have to pay attention to the dire warnings about layout on the data sheet. You can't just plop parts down on the board in any old fashion and expect it to work. One can extend this caveat to all circuits. The board must be considered a component.
And as we well know, a simulation is only as good as the models used, and finding accurate models of inductors and transformers is not easy.