Looks like they're ~50 Ohm SE impedance diff pairs, so the usual applies:
Don't cross GND slots, reduce crosstalk by keeping the offenders away by 5-10 prepreg heights, either don't flood top layer with GND, or if you do, stitch it every 1/10th wavelength of the signal in question, etc etc.
It doesn't seem particularly sensitive, just like most high-speed controlled impedance interfaces.