Er, it does what it says it does... clamps ESD?
Wouldn't be a good idea from a 12V supply, they're basically 3.3 and 5.0V zeners (respectively). Wired in pairs back to back, to get the bidirectional behavior.
Note that the clamp voltage is more like 10V under transient conditions -- there's no such thing as absolute "3.3V and nothing more". It wouldn't be a great idea to connect one directly across a sensitive logic input, for example, but it would be fine with a series resistor inbetween.
Tim