Let's suppose I'm interested in measuring the voltage response of a DUT to some imposed voltages. The DUT takes V1, V2, V3 as inputs relative to some GND, and outputs V4 relative to the same GND. All signals are below 100 kHz, and there's a 4 m run of wire. Is there any benefit in using four twisted pairs (V1, GND), (V2, GND), (V3, GND), (V4, GND), where for each twisted pair, one of the leads is bonded to ground, and the twisted pair is either stimulated (in the case of an input) or sensed (in the case of an output) by a differential circuit. The DUT can not be extended with differential drivers (it will be deep inside a cryostat at 300 millikelvin.)