I have been involved in using the Prius inverter (Gen. 2 and 3) for other applications before, and I would definitely not recommend it for this purpose. The MG1/MG2 IGBTs are dimensioned for hundreds of amps, and they are pretty slow. To keep switching losses manageable, you need to operate in the 5 - 20 kHz range, which means large magnetics, and efficiency won't be amazing in any case. Also, you would be using the phase current transducers at a small fraction of their intended range, exaggerating the effects of offsets and noise. Thirdly, you need water-cooling which is a large burden for a project in the sub-10 kW class. I would design something from scratch here, which might be a bit more effort but also a valuable experience, if you are comfortable working with the voltages and currents involved.
Boost followed by an inverting buck-boost would be my suggested approach, but a full-bridge with a center-tapped voltage doubler on the output side (with separate inductors per rail) is also an option, especially if the cross-regulation is not extremely critical. The latter options will likely be easier to compensate too, due to a lack of any right half plane zeros in the plant transfer function and the lack of cascaded converters.
I'll add a few notes based on my own experiences. Generally, I'd recommend fully galvanically isolated drivers for both low and high side devices, they are much less sensitive to switching node undershoot and ringing than the common high/low side driver options. Also observe the CMTI rating of any high side drivers, though with only a few hundred volts on the primary side this is less likely to be an issue. Hardware protection (especially during prototyping) is often a lot cheaper than even a single set of new power devices and gate drivers. And at these voltages and power levels, failures tend to be pretty catastrophic. I've still lost some hardware through stupidity (and most of the time, the hardware ends up being a total writeoffs), but the hardware protections have saved us around a hundred times as much carnage. Current mode control is nice and simplifies a lot of things, while overcurrent protection is mandatory. Also output overvoltage protecion on converters with a boost-type transfer function.