I've had a similar thing happen before, in an instrumentaion amplifier circuit, which had a much higher gain, than it should, causing a huge offset and the output to saturate, with the tiniest signal. The fault was was a 64R65 precision resistor, which measured the correct value, when removed from the board, but dropped to 5R, when soldered in. After wasting a lot of time, I noticed the value could be change from 64R65 to 5R manipulating one of the leads. I still don't understand how this could have happened. My guess is the connecting was short-circuiting when the lead was moved, but it seems odd, considering it was in an axial, plastic, through hole package.