I would look for a hard short circuit, maybe a main B+ or B- shorted to chassis, shorted main filter cap, shorted output transistors, etc.
ALSO, since the fuse blowing started after other work was done, my first move would be to double check that I had not done something wrong to cause it.
For example, the small transistor you replaced might have had the wrong basing, or inserted backwards - like that.
Of course now there is other damage also, so that will need to be tended to as well.