Did you get it like this or did it suddenly break? If so, did anything particular happen to it before it broke?
Did you measure both voltage and ripple on all power rails (+/- 18V floating, +5V floating, +5V earthed, 6VAC for front panel)? Ideally you use a scope to measure.
The blown fuse and damaged C109 cap (in parallel with the MOV) both suggest excessively high input signals, though on different inputs. But otherwise after the power rails I'd start looking at the floating or front panel logic circuits. Study what the service manuals says about start up steps (does all segments lighting up indicate correct operation of the front panel?), and based on that identify a suspect. Then look for clock, activity on address bus, reset line, etc.
Can you connect to it using RS-232 or GPIB? Maybe it's just the front panel that locks up.