Launch HxD and open a non-working hex dump.
Got to offset 0 and drag your cursor over the 0x100 bytes of data between
offsets 0 - FF. Those 0x100 bytes should be highlighted.
At the bottom of the screen you should see ...
Offset: 0
Block: 0 - FF
Length: 100
Overwrite
Now go to Search -> Find, select Datatype -> Hex-Values, place your cursor
in the "Search for" box and then type Ctrl-V. Then click OK.
Hit the F3 key to search for this block of data and keep hitting the F3 key
to repeat the search. Now do you see the problem?
To compute the checksum for your hex dump, select Analysis -> Checksums ->
Checksum-16 -> Entire File.