Like any thread that has sat tightened for decades they've sweated and frozen some onto the threads.
There's an arsenal of tricks that mechanical engineers use:
Heat
Penetrants
Percussion, two main types.* (FBH)
Brute strength and ignorance.
Or a combination of any or all of the above.

Familiarity with the forces fasteners can handle (experience) and the correct tools for the job will loosen all but the most stubborn fasteners along with some brute strength.
Sometimes one must resort to destructive measures to get things apart like wringing the ba***rds neck or the good ol gas axe.

Personally I prefer the FBH (F***ing big hammer) or variants of it.

Blind fasteners like grub/hex/Torx screws have their threads loaded on one face only and the small clearances in a thread from one face to the other can be used to some advantage. This is where the FBH come into it's own.
You need get the percussion (shock) into the shaft of the fastener, just hard enough for the end of the fastener to
bruise the surface it's wound down onto and lighten the pressure on the thread faces, breaking the bond at the same time. On small delicate fixtures the offside need be supported with something that can cushion the impact and yet has a similar or greater mass than the FBH. (1)
A few measured clouts with your FBH or FsmallH should shock the thread to and fro enough to break the decades old bond of the threads and loosen the tightness of the fastener, hopefully for it to be easily unwound.

As far as TE, the tightest grub screws I've come across was an old HP 1740A.......so tight that I didn't dare attempt to try to undo until I had the
perfect fit hex keys. And they were tight, bloody tight but all came undone without further tricks.

Gentle thermal cycling and penetrants can sometimes be useful for delicate patients and when you're stumped and not getting anywhere fast......sleep and worry about it later. You'd be surprised how a fresh mind looks at things differently.

* 1. Percussion with a FBH and a dolly (1) on tight nuts will swell the nut and break the bonds.
2. Use of some thin drift to get the impact onto the shank of the fastener so to not damage the hex, Torx etc.