After putting the board aside for a while, simply because I didn't have the tools at hand to investigate this further I've now upgraded and decided start another attempt. It turns out that my initial assumption that the DSPIC might have shorted out was wrong. I took the chip off, as well as both IS1543 and TS1542 and the short is still present. Currently my attention is again on IS2401 which as suggested Teichhermelin might be an IRAM535-1065AS. Unfortunately I did not find any datasheet for that IC. I tried to find out as much as possible about how the chip is wired with the DMM. I marked the connections in the image below, green traces are connected to ground, red traces are non-ground connections between endpoints. What currently seems odd to me is that the three dedicated pins A, B, C, which lead to the resistor banks above L1601 are all short to ground as are the two pads for a (now removed) ceramic cap next to C1603 . Also the pads of pins 8 and 9 of IS2401 are shorted to ground, while the pins are not shorted inside IS2401 itself, the resistance between pin 8 and 9 is around 100k Ohm. So there seems to be sth. wrong. Does anyone know how those IRAM535-1065AS work? To me it seems odd that pins A, B, C are all connected to ground, but three distinct traces are routed to the resistor banks above L1601. Since the short shows up everywhere on the board but does not seem to be tied to any component I now wonder if the short is within the PCB itself.