Hi!
Thanks for posting the schematic – it helps me give you accurate tips!
There are a number of things to check in the preamplifier chain before you get to the ASIC you replaced, and there's another Prema OEM special part that needs to be ruled out first!
To begin with, check the +5V. +15V and -15V lines are OK on the preamp board, then make sure the +7V feeding the amplifier block "SH10" is OK – this is a simple ovened zener regulator diode U4 LM399 that's designed to deliver a very stable and accurately trimmed reference voltage over a long period of time, and normally runs very hot to the touch as it contains it's own heater – it's mounted in a circular off–white ceramic package.
Feel this device very carefully with just the briefest touch of your finger – if it's very hot, check the +7V from it at the junction of S22/C15/SH10 – if low or missing either U4 or the SH10 module could be defective, and desoldering the pin of SH10 connected to the +7V rail will isolate the module from U4. If the +7V is being affected by SH10 you'll need to talk to Prema again about a replacement SH10 module!
If U4 is cold and/or there's no +7V at all, bin it and get a replacement LM399H!
If the +7V is OK and U4 is very hot, connect a 1K potentiometer across a 9V PP3/1604 battery and adjust the potentiometer to give about 200mV DC between wiper and negative, connect positive from pot wiper to Pin 3 (+ input of U3, LF411 buffer amplifier) and negative to meter 0V rail – the Meter's display should respond to this without causing an overflow!
If no response or change at all, again U3 or the SH10 module might be defective!
If ok at this point, try the same 200mV at pin 3 of U2 (+ input of '7650 chopper–stabilised amp) – no change here but OK at U3 pin 3 points to U2 or it's associated power supply etc., being defective, or possibly either (or both!) of the protection diodes CR4 & CR7 (PAD50, 5pA ultra–low leakage!) short circuit!
If CR4/CR7 are duffy you MUST get proper ultra–low leakage (5pA or less!) reverse current diodes as replacements – '4148s, etc., will NOT do – you'll never get the meter to zero properly unless you fit the correct types!
If you get a display change at U2 pin 3 with 200mV applied, then you're looking at the switching and voltage–divider components, which are self–explanatory from the circuit–diagram, which is drawn in the "DC Volts" position!
If you get the DC voltage ranges to respond but no "Ohms", measurements, check Q1, Q2, U1 and their associated components, and switch contacts S1, S2, S4, S5 and S22 are making when Ohms is selected, and any associated PCB tracking, joints, etc!
If you find the switch contacts S1 to S24 are not opening/closing at all when the front panel operation keys are pressed, you'll need a scope' to check the outputs from U10 pins 4–10 and 12, unfortunately Prema don't give a truth–table for the operation of U10, but it shouldn't be too difficult to compile your own!
Remember the relays K1 to K8 are self–latching pulse–operated types driven from the pins of U10 – the meter is designed like this to improve the noise immunity from random d.c. or a.c. voltages finding their way in from stray pick–up, etc!
A carefully placed ear should pick up faint clicks from the relays when you prod all the various front–panel keys, also, are there any sounds of clicking–noises during switch–on/self test? If there is then at least U10 is driving the relay coils during the self–test phase!
Faults in U10 or the relays themselves, again, need a chat to Prema about spares!
This is a reasonably straightforward DMM to fault–find but does rely entirely on OEM support because they've used custom ASIC devices in many places!
See how you go with all the above and come back if still stuck!
Chris Williams