I typically use the simulator extensively, then assemble on breadboard, then design a PCB and have it made by a professional company.
I have also used stripboard for permanent device with 6mm sleeved wires for connections. Even though the circuit was relatively simple, the wires underneath were quite cluttered.
Out of curiosity how do you solder enamel wire especially the thin ones? Or how do you strip off the enamel? On thicker wires I use a special file, but on thin ones it is a pain.