Lots of good points in this thread.
Keep in mind that ESD damage can be cumulative, i.e. it may not be evident right away. So, if you're working on anything you know is ESD sensitive which you will ultimately be sending out into the world for someone to use, always use proper ESD handling procedures.
If you're just doing personal test work at home/office and don't care, then do whatever is convenient and see what happens. I do this. About once a month, I end up with an IC that either stops functioning completely, or ends up with a pin that sinks waaaaay too much current. The likely cause is ESD damage. Once in a while I know it is EOS due to general carelessness with test leads and such, but more often than not, I am sure that I have not EOS'ed the pin and the only logical explanation is ESD damage.