In general - a turn wound against the main winding direction create local cancellation and reduce the overall efficiency. Any inconsistency in the winding uniformity may introduce parasitic resonances, which degrade performance, especially at higher frequencies.
When it comes to antennas, especially air-core loop antennas, the winding style affects both inductance and Q-factor. For tuned or high-Q loops, uniform helical or flat spiral windings are preferred.
Also, wire length matters. Longer wire means higher resistive (thermal) losses. For VLF and low-frequency applications, ferrite rod antennas are often a better choice for receivers. They’re compact, require much less wire than air-core loops, and therefore exhibit lower resistive losses. Ferrite saturates easily, so it's not suitable for transmitting antennas, but for receiving - especially in portable or space-constrained designs - it’s ideal.
However, I would caution against the misconception that a physically small antenna inherently requires less surrounding space. In practice, electrically small antennas often demand just as much, if not more, clear space around them. This surrounding volume must remain free of conductive or dielectric materials and noise sources (such as electronic devices), as nearby objects can significantly impact radiation efficiency, introduce additional losses, and distort the radiation pattern.