Losses are a bit higher. For HF, probably not a concern.
You can't really connect pairs in parallel or series, because their velocities aren't matched. (Again, may not be a problem for HF, but beware.) Obviously, it's not coax and it's not 50 ohm, so you'll need a matching balun, or else your transmitter and antenna grounds will fry everything, even for QRP.
The additional wires probably need to be well filtered. Theoretically they are all balanced, but if your balun isn't ideal, for example, expect coupling. If the control signals are slow anyway (provide filtering at both ends if they are driven by switches), using them in an unbalanced manner would be okay.
Tim