Found this on page 53 of this manual
https://www.artisantg.com/info/Agilent_E5378A_Manual.pdf :
Clock inputThe clock input to the E5378A probe is differential. If you supply a differential clock, you should select the "differential" option in the clock threshold user interface.
If your system uses a single-ended clock signal, the CLKn input should be either grounded or connected to a dc power supply.
You may:
• Ground the CLKn input and adjust the clock threshold from the user interface to between -3V dc and +5V dc.
Or
• Supply a threshold reference voltage between -3V dc and +5V dc to the CLKn input. In this case, the clock threshold in the user interface should be set to zero.
If your circuit uses a resistive divider to provide a threshold reference, be sure to consider the equivalent circuit consisting of the 20k resistor connected to +0.75V
as shown on page 34 and 35.
The threshold for the clock input has a separate adjustment in the user interface, independent of the data inputs.