I have done it enough time with the Fluke when I was in a hurry tried to measure voltage (120V to 480V) with the test leads plug into the current measurement jack. It blewd the fuse but I am glad that it blew the expensive fuse because the cheap fuse may explode.
No argument, sometimes a blown fuse can be a huge bargain. But generally, electricity is not something that is intentionally trying to kill you. Human beings are more dangerous in that regard. Flukes are a nice toys, no doubt and sometimes they can be of very high value. Imagine you gave to someone a tool to do the work and the shit happened. I doubt the lawyers will consult with Charles Darwin about the root cause of the accident. They likely will demonstrate their professionalism trying to make you responsible. At that time, Fluke can protect you very effectively.
But I'm not sure it's the best brand for casual use. Once I was preparing to long distance car trip and bought a couple of cheap rugged multimeters of random brand (see the image). One for myself and one for use at work by all, to check power supply voltages before connecting the boards. I was considering it an expendable thing, but it continues to work fine for many years, to my surprise. Never blown the fuse so not sure what will happen, but a lot of mechanical abuse, winter work outside, etc. Still works and I'm using it for occasional LV repairs and in car. It displays something that looks plausible and that's all I need. Anyway a serious work is done in the lab so I'm not sure a handheld device needs to be of high accuracy.
BTW, based on the bright pictures at the Uni-T site, it seems I was wrong. It was UT71 multimeter, not UT61. The guy was very proud of himself and I was afraid of insulting him with a cheap gift. UT71 looks more professionally, it's something comparable to Fluke 189 so no one could say that mine is better so all were happy.