Since we're using the Ah accumulation facility, we're not going to be able to compare other Keithley SMUs here. The current reading is always accurate. But, as the accumulator gets larger, the accuracy of that accumulator reduces.
It would be a fair limitation if it could only accumulate up to, say, 100,000 Ah before reporting a saturation error, but this occurs very early on at a charge of around 300uAh, which is really not much, I mean you'd expect many smartphones to eat through that just flashing up a notification or something like that, yet they advertise this instrument as "perfect" for evaluating such devices.
A 64-bit fixed point accumulator would allow a high 100kAh max accumulation while having a lower bound of around 5 femto-amphours