I dont know this meter, i'm not sure if it has a talk option like the 34401a
Talk means, it will output the measured values only, no controls over rs232
In the user manual, they just say cross the TX and RX pins between the meter and pc, and the meter configurations settings
Do you use an USB to rs232 adapter ?
You could connect it with the usb cable, you need usbtmc drivers or the keysight software .... if you want to control it, use old i/o library suite for the dmm connectivity software
IOLibSuite_17_1_19313.exe
DMM_Connectivity_Utility_1.0.2.0.exe
They support my 34410a ... should do okay for the 34450a