Frank -- Thank you for heads-up on the 34465A. I reviewed the Keysight spec sheet and it says: "The ability to measure very low current, 1-microamp range with pA resolution, allows you to make measurements on very low power devices."
http://literature.cdn.keysight.com/litweb/pdf/5991-1983EN.pdf?id=2318052
Resolution on a 6-digit meter with a 1-microamp range will have a pA of resolution. 3 digits for nA and 3 digits for pA. Is that correct? That's my understanding, anyway. A 100-microamp 6-digit meter (say, the 34461A) should then have a 100-pA resolution. Can I safely assume that these meters are "accurate" to their "resolution?" I realize that manufacturers are sometimes lose with their usage of accuracy, resolution, repeatability, etc. I also realize that measurement accessories (leads, probes, etc.) must have some special requirements.
I apologize for the naive questions. Most of my meter requirements have fallen within 1-sigma of most meters' abilities. Thanks for the heads-up on the digitizing option. Noodling that.
Your ideas about the resolutions are correct, but ONLY in the steady state, i.e. at NPLC 100.
The accuracy is NOT the same as resolution, the specification indicates of course less accuracy than corresponding resolution, in terms of (error of reading + error of range).
Resolution is about 1 ppm (NPLC 100), but accuracy is in the ballpark of 100pm.
I think, accuracy is not the crucial parameter for this application.
For fast changing signals, you also have to sample the current accordingly faster, which will reduce the resolution of your measurement!
At fast sampling rates, the system noise of the DMMs might also increase.
The 8846A and the 34461A are similar instruments, also concerning speed vs. resolution.
For both, the resolution will go down, from 6 1/2 digits at 100 NPLC to 4 1/2 digits at 1000 samples/sec (300µs aperture).
The 34465A is much better in this aspect, still delivering 5 1/2 digits at that speed.
Here are the resolution tables, from the 3446xA and 8846A manuals:


Rem.: The 34465A and 34470A both deliver more digits over the interfaces (GPIB, USB, LAN), than on the display, e.g. 0.1ppm resolution at NPLC10.
I have measured , that there is no difference between the 34465A and 470A in this aspect, so the resolution of the '470A might apply.
You have to figure out on your own, how fast your DUT might be, so what sampling rate is needed, and what dynamic is needed, which is critical in these low power systems, as the ratio between idle and power on state usually is extremely high.
Btw.: Comparing prices, the Fluke 8846A is about 1600€, and the 34461A is 1120€ only.
The 34465A is better / faster (5kSa/s at 200µs aperture) than both other instruments, and costs 1426€, plus 400€ if you need the (faster) digitizing option (up to 20µs/50kSa/s).
The proposal, to use handheld DMMs, or Daves µCurrent, will not work at all, as an instrument with fast sampling capability (< msec aperture / speed) AND high resolution is needed.
Handheld DMMs are not suitable, as they have 10 rdgs/sec at most.
So they simply average out any short current spikes.
Frank