First: yes you definately will have to adjust it after transportation. But this is a quick and easy task. You will find the Operating Instructions And Service Manual (25 pages) of the Mantis on the net, if not I can send you a PDF if you like.
I am using both, a stereo microscope and a Mantis, though 99,9% of the time the Mantis is preferred.
If you only need to work for a few minutes on a chip, a stereo microscope is fine but after 15 minutes you will feel the difference in your neck ...
Yes you need to keep your head at the sweet spot as the Mantis is still a pure optical system like the microscope. It is not a monitor, you still have a real 3D view which makes working / inspection much easier than a 2D view on a monitor.
What I would strongly propose is the 6x SLWD lens (there is one on Ebay right now) as it allows a much higher working distance and thus it brings the head up approx. another 10cm (makes working easier). Also a height-adjustable desk would be perfect (which I do not have by now).
The latter two tips are also helpful for a regular stereo microscope - here a x0.35 lens will allow you a large working distance and less neck problems as the oculars are then located much higher.