I have looked at your maps...
ds250C_we.crs
ds250C_we_ap_fi_le_static.gan
Using my DevTools:
http://joe-c.de/pages/posts/programm_dev_tools_133.php#bilder
the first looks ok, but the Second has a calibrated Spot at this point you see in your picture.
But... why the Spot is at another place compared to the fist image that tomas123 found? 
i make a red rectagle from Spotcenter to the dust point.
Additional... the old Picture with the near spots as a "hotspot" (color level higher), the other you send is a "coldspot" (color level lower)...
if this is really from the same camera?
May be it is inside the sensor module.
Maybe... but if the dirt falls from his place at the calibration, this place could now receive more radiation and the internal calibration over compensate this...
and this should finish in a Hot spot...
But Maybe... i am just wrong 

Thank you for your analysis.
The image with orange background is really NOT from my camera, it's an image quoted by Thomas123 to show me how to clean the sensor properly : )
FLIR114 is before I did any cleaning, the spot was almost disappear on hot and cold object. Only became visible on uniform object that near room temperature.
FLIR146 is after the cleaning. The spot is easily visible at different temperature range, especially on cold object but almost disappear on hot object (>40 degree Celsius).
I think the spot is always at that location.
update: I added a gif animation below.
Tiny dust marks can be near impossible to see but could be dirt inside.
The sensor has a 10 year warranty from Flir (2 years on rest of camera). May be best to reset any software modifications and send to Flir.
The problem is, that speck could have been there from factory, but since the detector is cropped, it wouldn't be apparent to anyone thinking they had just bought a camera with 80x60 - how would you explain it to FLIR that you hacked it to full resolution and discovered the spec?
And when my E4 @80x60 with noise level 135, that spot is near invisible. (80x60 is almost enough to mask that spot, with noise 135 it masks every thing and its ready to release to the market.They don't need any firmware/hardware lock, just selling such kinds of thing and you wont be happy after hacking/unlock/mod. I hope they didn't introduce "dead pixel generator" ha haha)