If it's a USB mouse, the controller inside the mouse needs to support both USB and PS/2 ... usually the controller tries to communicate through USB and if it can't detect valid usb packets within some period of time, it assumes the protocol is PS/2 and falls back to that.
You should be able to easily get older optical mice at goodwill or some other places with such controllers, and worst case scenario you'd just have to replace switches inside to get partially working mice back to 100% operational state.
You can also buy new PS/2 mice from eBay, for example here's one for around 10-12$ plus shipping :
https://www.ebay.com/itm/316041299670--
I remember seeing some ISA usb controllers on Youtube on some of the channels that show older hardware and older games, and some dos usb drivers were shown ... but I don't remember exactly what channel was, sorry... either way, not sure if it's worth buying such card. A ps/2 controller card would be more common and use less resources.