What is the limitation you're facing with it currently? Sorry, but it wasn't explicit from your post.
Lack of support for larger hard drives? In that case, you could try
XTIDE. Either buy/make a dedicated boot ROM card, or put the ROM in another card that has a ROM socket (e.g. network card).
Or just the BIOS is bad/buggy? There is an Award BIOS listed on the
page for that motherboard on The Retro Web, but it is older than what you have, and only appears to be for revision 1.1 boards.
Why not swap out for something newer than 486? If you're restricted by need for supporting ISA cards, plenty of options using Pentium II/III, Cyrix, AMD, etc. that still have ISA and AT form factor.