In my experience, for about half a year Altium in Virtualbox has worked without problems, before it was unable to open pcb at all (some directx shader issues). But it is still unbearably slow in my i7-4600U laptop, integrated intel graphics, latest Linux Mint.
In wine it works much better, but there are some bugs, that cause crashes (especially one with 3d models that happens when changing component layer; there's a workaround for that). In addition, the SQL library integration did not work at all, so I have to use Virtualbox to pull in components from company db. Havent tried the AD18 beta yet.