Start again with a bigger PCB.
Drag all components outside the PCB margins.
Have the printed schematic handy or on a second display to constantly refer to while placing components.
Place first components that must be in a certain place. Lock them.
Then place the most complex components.
Slowly add other active components while still shifting already placed components to make room for passives yet to come.
As others have mentioned build and finalize circuit blocks of which you can select and move/rotate for best connectivity.
All the time you need consider how any and all components will be placed, soldered or reworked
and routed.
Use autoroute often to see what you can improve with better placement then un-route and move/rotate stuff.
Study old commercial PCB's......lots ! Understand signal/data connections
and power rail routing.
Use a pour to connect to as many components as you can, orientate them so that you can.
Eye up bigger components that might allow traces run under them and place them where this might help you.
Be prepared to spend real time on a good layout and don't be too impatient to do so.
After a couple of PCB's there'll be no stopping you and you'll spin them out in a fraction of the time your first one took.
Post your progress layouts for marking.
Daves good PCB guide:
http://www.alternatezone.com/electronics/files/PCBDesignTutorialRevA.pdfMore here:
https://www.eevblog.com/wiki/index.php?title=Online_Electronics_Tutorials_and_Books#PCB_layout_and_CAD